发明授权
US06645939B1 Substituted &bgr;-alanine derivatives as cell adhesion inhibitors
失效
取代的β-丙氨酸衍生物作为细胞粘附抑制剂
- 专利标题： Substituted &bgr;-alanine derivatives as cell adhesion inhibitors
- 专利标题（中）： 取代的β-丙氨酸衍生物作为细胞粘附抑制剂
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申请号： US09317789申请日： 1999-05-24
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公开(公告)号： US06645939B1公开(公告)日： 2003-11-11
- 发明人: Philippe L. Durette , William K. Hagmann , Ihor E. Kopka , Malcolm MacCoss , Sander G. Mills , Richard A. Mumford , Plato A. Magriotis
- 申请人： Philippe L. Durette , William K. Hagmann , Ihor E. Kopka , Malcolm MacCoss , Sander G. Mills , Richard A. Mumford , Plato A. Magriotis
- 主分类号： C07K506
- IPC分类号： C07K506
摘要：
&bgr;-Alanine derivatives of Formula I are antagonists of VLA-4 and/or &agr;4&bgr;7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.
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