发明授权
US06645969B1 Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
失效
抑制CSF-1R受体酪氨酸激酶的芳基和杂芳基喹唑啉化合物
- 专利标题： Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
- 专利标题（中）： 抑制CSF-1R受体酪氨酸激酶的芳基和杂芳基喹唑啉化合物
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申请号： US08521852申请日： 1995-05-18
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公开(公告)号： US06645969B1公开(公告)日： 2003-11-11
- 发明人: Michael R. Myers , Alfred P. Spada , Martin P. Maguire , Paul E. Persons , Asher Zilberstein , Chin-Yi Jenny Hsu , Susan E. Johnson
- 申请人： Michael R. Myers , Alfred P. Spada , Martin P. Maguire , Paul E. Persons , Asher Zilberstein , Chin-Yi Jenny Hsu , Susan E. Johnson
- 主分类号： A01N4354
- IPC分类号： A01N4354
摘要：
This invention relates to the modulation and/or inhibition of cell signaling, cell proliferation, cell inflammatory response, the control of abnormal cell growth and cell reproduction. More specifically, this invention relates to the use of mono- and/or bicyclic aryl or heteroaryl quinazoline compounds in inhibiting cell proliferation, including compounds which are useful protein tyrosine kinase (PTK) inhibitors. The method of treating cell proliferation and/or differentiation or mediator release using said quinazoline compounds and their use in pharmaceutical compositions is described.