发明授权
- 专利标题: Inhibition of TGF-&bgr; and uses thereof
- 专利标题(中): TGF-β的抑制及其用途
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申请号: US09679971申请日: 2000-10-05
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公开(公告)号: US06649588B1公开(公告)日: 2003-11-18
- 发明人: Siamak Tabibzadeh , James M. Mason
- 申请人: Siamak Tabibzadeh , James M. Mason
- 主分类号: A61K3800
- IPC分类号: A61K3800
摘要:
The present invention provides a method for inhibiting activity of TGF-&bgr;, comprising contacting tissue expressing TGF-&bgr; with an amount of ebaf or an ebaf analogue. The present invention further provides a method for treating a condition associated with overactivity of TGF-&bgr;, particularly fibrosis, a defect in cell proliferation, or a coagulation defect. The present invention also provides a method for inhibiting activity of TGF-&bgr;, comprising contacting tissue expressing TGF-&bgr; with a modulator of ebaf expression, or a modulator of expression of an ebaf analogue. The present invention is further directed to a method for treating fibrosis in a subject in need of treatment, comprising administering to the subject an amount of ebaf or an ebaf analogue effective to treat the fibrosis. Finally, the present invention provides a method for treating a defect in cell proliferation in a subject in need of treatment, comprising administering to the subject an amount of ebaf or an ebaf analogue effective to treat the defect in cell proliferation.