An interior rearview mirror audio system for a vehicle includes an interior rearview mirror assembly preferably comprising a plurality of microphones, a communication system of a vehicle and at least one manually actuated control input. The communication system includes a cellular telephone system and/or an emergency communication system. The communication system includes at least one communication device. The manually actuated control receives a manual input from an occupant of the vehicle and activates and/or adjusts the communication device of the communication system in response to the manual input. A control is preferably provided for receiving output signals of at least two microphones, the output signals comprising both vocal signals and non-vocal signals, and the control at least partially filtering out the non-vocal signals.