发明授权
- 专利标题: Pyrazole compounds useful as protein kinase inhibitors
- 专利标题(中): 用作蛋白激酶抑制剂的吡唑化合物
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申请号: US10027001申请日: 2001-12-19
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公开(公告)号: US06653301B2公开(公告)日: 2003-11-25
- 发明人: David Bebbington , Jean-Damien Charrier , Robert Davies , Julian M. C. Golec , David Kay , Ronald Knegtel , Sanjay Patel
- 申请人: David Bebbington , Jean-Damien Charrier , Robert Davies , Julian M. C. Golec , David Kay , Ronald Knegtel , Sanjay Patel
- 主分类号: A61K3133
- IPC分类号: A61K3133
摘要:
This invention describes novel pyrazole compounds of formula IIa: wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
公开/授权文献
- US20030078275A1 Pyrazole compounds useful as protein kinase inhibitors 公开/授权日:2003-04-24
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