发明授权
US06660756B2 N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
失效
N-苯丙基环戊基取代的戊二酰胺衍生物作为中性内肽酶的抑制剂
- 专利标题： N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
- 专利标题（中）： N-苯丙基环戊基取代的戊二酰胺衍生物作为中性内肽酶的抑制剂
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申请号： US10096218申请日： 2002-03-12
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公开(公告)号： US06660756B2公开(公告)日： 2003-12-09
- 发明人: Stephen Challenger , Andrew Simon Cook , Adam Thomas Gillmore , Donald Stuart Middleton , David Cameron Pryde , Alan Stobie
- 申请人： Stephen Challenger , Andrew Simon Cook , Adam Thomas Gillmore , Donald Stuart Middleton , David Cameron Pryde , Alan Stobie
- 优先权： GB0107750 20010328; GB0113112 20010530; GB0120152 20010817
- 主分类号： A61K3144
- IPC分类号： A61K3144
摘要：
The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alkoxy, —NR2 R3 or —NR4SO2R5; X is the linkage —(CH2)n— or —(CH2)q—O— (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxy(C1-3alkyl); C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.