发明授权
US06664393B2 N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
有权
N-胍基烷基酰胺,它们的制备方法,它们的用途以及包含它们的药物制剂
- 专利标题: N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
- 专利标题(中): N-胍基烷基酰胺,它们的制备方法,它们的用途以及包含它们的药物制剂
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申请号: US10227222申请日: 2002-08-26
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公开(公告)号: US06664393B2公开(公告)日: 2003-12-16
- 发明人: Otmar Klingler , Gerhard Zoller , Elisabeth Defossa , Fahad A. Al-Obeidi , Armin Walser , James Ostrem
- 申请人: Otmar Klingler , Gerhard Zoller , Elisabeth Defossa , Fahad A. Al-Obeidi , Armin Walser , James Ostrem
- 优先权: EP99121623 19991030
- 主分类号: C07D23924
- IPC分类号: C07D23924
摘要:
The present invention relates to compounds of the formula I, in which A, L, Y, and k have the meanings indicated in the specification and claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa and/or factor VIIa and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of conditions in which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.