发明授权
- 专利标题: Technetium-99m labeled peptides for imaging
- 专利标题(中): 锝-99m标记肽成像
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申请号: US08889212申请日: 1997-07-08
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公开(公告)号: US06667389B1公开(公告)日: 2003-12-23
- 发明人: Richard T. Dean , John Lister-James
- 申请人: Richard T. Dean , John Lister-James
- 主分类号: A61K5108
- IPC分类号: A61K5108
摘要:
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via (Tc-99m) binding moieties. In particular, the peptide reagents of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the specific-binding peptides, and the Tc-99m binding moieties are covalently linked to a plurality of the specific-binding peptides, the polyvalent linker moiety, or to both the specific-binding peptides and the polyvalent linker moiety.
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