In order to provide a rotary printing machine for direct printing, in which the printing-assembly cylinders are arranged in a space-saving way, there is arranged in side walls at least one double printing assembly containing two form cylinders which are located one above the other, each having its own drive motor and between which at least one impression cylinder is arranged, a web being printable between a form cylinder and an impression cylinder. Each form cylinder and the impression cylinder cooperating with the latter are mounted, adjustably in terms of their mutual spacing, in side walls of the printing unit. For this purpose, the adjustable cylinders are mounted on both sides in slides which are moveable on guide elements fastened to the side walls.