A prone positioning therapeutic bed comprises a base frame, a patient support platform rotatably mounted on the base frame for rotational movement about a longitudinal rotational axis, a drive system for rotating the patient support platform on the base frame, and an upright end ring at the head of the bed with a central opening for routing patient care lines and a removable upper section for improved access to a patient's head. The patient support platform preferably has pivotally mounted side rails that fold underneath the patient support platform and straps with strap connectors that indicate whether the straps are sufficiently tensioned. A direct, wired electrical connection between the patient support platform and the base frame allows full rotation of the patient support platform in either direction. A manually operable lever disengages the patient support platform from the drive system to allow manual rotation of the patient support platform.