发明授权
- 专利标题: Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
- 专利标题(中): 用于治疗和预防代谢性骨骼疾病的罗丹明羧酸衍生物
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申请号: US09787917申请日: 2001-06-21
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公开(公告)号: US06673816B1公开(公告)日: 2004-01-06
- 发明人: Angelika Esswein , Wolfgang Schaefer , Christos Tsaklakidis , Konrad Honold , Klaus Kaluza
- 申请人: Angelika Esswein , Wolfgang Schaefer , Christos Tsaklakidis , Konrad Honold , Klaus Kaluza
- 优先权: EP98118493 19980930
- 主分类号: A61K31426
- IPC分类号: A61K31426
摘要:
Compounds of general formula (I), in which m is 0-8, q is a 0-8, a is 0-4, A signifies a single or double bond, R1, R2 signify hydrogen or lower alkyl and, when m signifies 2-8, R1 and R2 in the group CR1═CR2 can have various significances within the following sequence, R3 signifies hydrogen or lower alkyl, X signifies hydrogen or —(CH2)b—COR4 with b=0-4, Y signifies hydrogen, —COR4, phenyl or indolyl residue R4 signifies hydroxyl, lower alkoxy or the NR1R2 residue, W signifies an optionally mono- or polysubstituted saturated or unsaturated mono-, bi- or tricycle which can contain hetero atoms, as well physiologically compatible salts, esters, optically active forms, racemates, tautomers, and derivatives which can be metabolized in vivo to compounds of general formula (I).
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