Techniques for canceling pilot interference in a wireless (e.g., CDMA) communication system. A received signal typically includes a number of signal instances (i.e., multipaths). For each multipath desired to be processed, the other multipaths act as interference on the desired multipath. If the pilot is generated based on a known data pattern (e.g., all zeros) and covered with a known channelization code (e.g., a Walsh code of zero), then the pilot in an interfering multipath may be estimated as the spreading sequence at a time offset corresponding to the arrival time of that multipath. The pilot interference from each interference multipath may be estimated based on the spreading sequence for the interfering multipath and the despreading sequence for the desired multipath. The total pilot interference from a number of interfering multipaths may be subtracted from the data component in the desired multipath to provide pilot-canceled data having improved performance.