发明授权
US06683093B2 Aromatic sulfone hydroxamic acids and their use as protease inhibitors
失效
芳香砜异羟肟酸及其作为蛋白酶抑制剂的用途
- 专利标题： Aromatic sulfone hydroxamic acids and their use as protease inhibitors
- 专利标题（中）： 芳香砜异羟肟酸及其作为蛋白酶抑制剂的用途
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申请号： US09989943申请日： 2001-11-21
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公开(公告)号： US06683093B2公开(公告)日： 2004-01-27
- 发明人: Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , Jeffery N. Carroll , Gary A. DeCrescenzo , Yvette M. Fobian , John N. Freskos , Daniel P. Getman , Joseph J. McDonald , Madeleine H. Li , Susan L. Hockerman , Carol Pearcy Howard , Steve A. Kolodziej , Deborah A. Mischke , Joseph G. Rico , Nathan W. Stehle , Michael B. Tollefson , William F. Vernier , Clara I. Villamil , Darren J. Kassab
- 申请人： Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , Jeffery N. Carroll , Gary A. DeCrescenzo , Yvette M. Fobian , John N. Freskos , Daniel P. Getman , Joseph J. McDonald , Madeleine H. Li , Susan L. Hockerman , Carol Pearcy Howard , Steve A. Kolodziej , Deborah A. Mischke , Joseph G. Rico , Nathan W. Stehle , Michael B. Tollefson , William F. Vernier , Clara I. Villamil , Darren J. Kassab
- 主分类号： A61K31445
- IPC分类号： A61K31445
摘要：
This invention is directed to aromatic sulfone hydroxamates (also known as aromatic sulfone hydroxamic acids) and salts thereof that, inter alia, tend to inhibit matrix metalloproteinase (also known as matrix metalloprotease or MMP) activity and/or aggrecanase activity. This invention also is directed to a treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP activity and/or aggrecanase activity.
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