发明授权
US06685938B1 Methods and compositions useful for modulation of angiogenesis and vascular permeability using SRC or Yes tyrosine kinases
有权
用于调节血管生成和血管通透性的方法和组合物使用SRC或是酪氨酸激酶
- 专利标题： Methods and compositions useful for modulation of angiogenesis and vascular permeability using SRC or Yes tyrosine kinases
- 专利标题（中）： 用于调节血管生成和血管通透性的方法和组合物使用SRC或是酪氨酸激酶
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申请号： US09470881申请日： 1999-12-22
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公开(公告)号： US06685938B1公开(公告)日： 2004-02-03
- 发明人: David A. Cheresh , Brian Eliceiri
- 申请人： David A. Cheresh , Brian Eliceiri
- 主分类号： A61K3845
- IPC分类号： A61K3845
摘要：
The present invention describes methods for modulating vascular permeability (VP) in tissues using Src or modified Src protein, Yes protein or modified Yes protein, or mixtures thereof, and nucleic acids capable of expression such proteins. In particular, the invention describes methods for inhibiting VP using an inactive Src or Yes protein or a mixture thereof, or nucleic acids encoding therefor, or for potentiating VP using an active, Src or Yes protein or a mixture thereof, or nucleic acids encoding therefor. Related compositions and articles of manufacture are also disclosed.
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