发明授权
- 专利标题： Triphosphate oligonucleotide modification reagents and uses thereof
- 专利标题（中）： 三磷酸寡核苷酸修饰试剂及其用途
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申请号： US09630627申请日： 2000-08-01
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公开(公告)号： US06686461B1公开(公告)日： 2004-02-03
- 发明人: David A. Schwartz , Richard I. Hogrefe
- 申请人： David A. Schwartz , Richard I. Hogrefe
- 主分类号： C07H1904
- IPC分类号： C07H1904
摘要：
Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
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