发明授权
US06699686B1 Modified nuclear glucocorticoid receptor, fusion protein, and DNA fragments coding for said receptor and said fusion protein
失效
修饰的核糖皮质激素受体，融合蛋白和编码所述受体和所述融合蛋白的DNA片段
- 专利标题： Modified nuclear glucocorticoid receptor, fusion protein, and DNA fragments coding for said receptor and said fusion protein
- 专利标题（中）： 修饰的核糖皮质激素受体，融合蛋白和编码所述受体和所述融合蛋白的DNA片段
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申请号： US09125491申请日： 1998-08-20
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公开(公告)号： US06699686B1公开(公告)日： 2004-03-02
- 发明人: Jacques Bertrand Brocard , Pierre Henri Chambon , Hinrich Gronemeyer , Daniel Metzger , Jean-Claude Nicolas , Sylvie Roux
- 申请人： Jacques Bertrand Brocard , Pierre Henri Chambon , Hinrich Gronemeyer , Daniel Metzger , Jean-Claude Nicolas , Sylvie Roux
- 优先权： FR9602060 19960220
- 主分类号： C12N1500
- IPC分类号： C12N1500
摘要：
A DNA fragment coding for a modified nuclear glucocorticoid receptor, particularly one mutated in the region coding for the ligand binding domain, so that receptor activity is more strongly inducible by a synthetic glucocorticoid ligand than by a natural glucocorticoid ligand, is disclosed. A recombination system inducible in mammals by means of a fusion protein produced between a recombinase and the binding domain of the ligand derived from the modified glucocorticoid receptor of which the activity is more strongly inducible by synthetic glucocorticoids than by natural glucocorticoids, is also disclosed.
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