发明授权
- 专利标题： Methods for the stereoselective synthesis of substituted piperidines
- 专利标题（中）： 立体选择性合成取代的哌啶的方法
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申请号： US10012242申请日： 2001-12-04
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公开(公告)号： US06703508B2公开(公告)日： 2004-03-09
- 发明人: Brian M. Aquila , Thomas D. Bannister , Gregory D. Cuny , James R. Hauske , Michelle L. R. Heffernan , Michael Z. Hoemann , Donald W. Kessler , Liming Shao , Xinhe Wu , Roger L. Xie
- 申请人： Brian M. Aquila , Thomas D. Bannister , Gregory D. Cuny , James R. Hauske , Michelle L. R. Heffernan , Michael Z. Hoemann , Donald W. Kessler , Liming Shao , Xinhe Wu , Roger L. Xie
- 主分类号： C07D21130
- IPC分类号： C07D21130
摘要：
One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in the synthesis of compounds useful for treatment of numerous ailments, conditions and diseases that afflict mammals, including but not limited to addiction and pain. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the substituted piperidines using the methods of the present invention. An additional aspect of the present invention relates to enantiomerically substituted pyrrolidines, piperidines, and azepines.