An apparatus for and a method of ensuring that a non-speculative instruction is not fetched into an execution pipeline, where the non-speculative instruction, if fetched, may cause a cache miss that causes potentially catastrophic speculative processing, e.g., speculative transfer of data from an I/O device. When a non-speculative instruction is scheduled for a fetch into the pipeline, a translation lookaside buffer (TLB) miss is made to occur, e.g., by preventing the lowest level TLB from storing any page table entry (PTE) associated with any of the non-speculative instructions. The TLB miss prevents the occurrence of any cache miss, and causes a micro-fault to be injected into the pipeline. The micro-fault includes an address corresponding to the subject non-speculative instruction, and when it reaches the end of the pipeline, causes a redirect of instruction flow of the pipeline to the address, and thus the non-speculative instruction is fetched and executed in a non-speculative manner.