发明授权
- 专利标题: Substituted heterocycle fused gamma-carbolines
- 专利标题(中): 取代的杂环稠合的γ-咔啉
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申请号: US09594954申请日: 2000-06-15
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公开(公告)号: US06713471B1公开(公告)日: 2004-03-30
- 发明人: Albert J. Robichaud , Taekyu Lee , Wei Deng , Ian S. Mitchell , Simon Haydar , Wenting Chen , Christopher D. Mc Clung , Emilie J. B. Calvello , David M. Zawrotny
- 申请人: Albert J. Robichaud , Taekyu Lee , Wei Deng , Ian S. Mitchell , Simon Haydar , Wenting Chen , Christopher D. Mc Clung , Emilie J. B. Calvello , David M. Zawrotny
- 主分类号: C07D26722
- IPC分类号: C07D26722
摘要:
The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8, R9, X, b, k, m, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.