发明授权
US06713517B1 Use of aryl N-substituted carboxamides directly and as radio-and chemosensitizers for killing tumor and cancer cells and novel compounds for such use
失效
直接使用芳基N-取代的甲酰胺和作为放射性和化学敏化剂杀死肿瘤和癌细胞以及用于此类用途的新化合物
- 专利标题： Use of aryl N-substituted carboxamides directly and as radio-and chemosensitizers for killing tumor and cancer cells and novel compounds for such use
- 专利标题（中）： 直接使用芳基N-取代的甲酰胺和作为放射性和化学敏化剂杀死肿瘤和癌细胞以及用于此类用途的新化合物
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申请号： US08807497申请日： 1997-02-27
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公开(公告)号： US06713517B1公开(公告)日： 2004-03-30
- 发明人: Ronald W. Pero , Anders Olsson , Tomas Ekberg , Alan Schwartz , David Chaplin
- 申请人： Ronald W. Pero , Anders Olsson , Tomas Ekberg , Alan Schwartz , David Chaplin
- 主分类号： A01N3718
- IPC分类号： A01N3718
摘要：
Methods of killing tumor or cancer cells in human patients using an aryl N-substituted carboxamide having one or more aryl halo or one or more aromatic nitrogens, and/or acid addition salts thereof. The carboxamide may be an N-substituted nicotinamide or an N-substituted benzamide having such features, and may be used directly as a chemotherapeutic agent, or as a sensitizer for radiation or other chemotherapeutic agents. New compositions for such use include N-(2-diethylamino-ethyl)-4-amino-3-chlorobenzamide, N-(2-diethylamino-ethyl) nicotinamide, and their acid addition salts, e.g. hydrochlorides.
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