The invention provides a method of driving a piezoelectric transformer and a power source apparatus using the same. For a circuit for driving a piezoelectric transformer which steps up a voltage input from a primary electrode by a piezoelectric effect to output the stepped up voltage from a secondary electrode, the gradient (linear differential value) of a step-up ratio at the piezoelectric transformer is detected, and the detected gradient is used to control the driving frequency for the piezoelectric transformer so that the driving frequency approaches to the resonant frequency of the piezoelectric transformer.