发明授权
US06733963B2 Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics
失效
用于鉴定作为抗生素的3-异丙基苹果酸脱水酶抑制剂的方法
- 专利标题： Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics
- 专利标题（中）： 用于鉴定作为抗生素的3-异丙基苹果酸脱水酶抑制剂的方法
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申请号： US10010227申请日： 2001-12-06
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公开(公告)号： US06733963B2公开(公告)日： 2004-05-11
- 发明人: Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer
- 申请人： Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer
- 主分类号： C12Q100
- IPC分类号： C12Q100
摘要：
The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
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