In a multi-piece solid golf ball comprising a solid core and a cover of two inner and outer layers enclosing the solid core and formed on the surface with a plurality of dimples, the solid core in its entirety has a hardness distribution falling within the range of JIS-C hardness 50-85, the difference between maximum and minimum JIS-C hardnesses in the solid core falls within 5%, the cover inner layer has a JIS-C hardness of 70-90, the cover outer layer has a JIS-C hardness of 60-80, the sum of high-speed region dimple operative volumes HDOV of respective dimples is 170-310, the sum of low-speed region dimple operative volumes of respective dimples LDOV is 200-310, and the overall dimple volume is 260-360 mm3.