发明授权
US06743594B1 Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
失效
使用人G蛋白趋化因子受体HDGNR10（CCR5）进行筛选的方法
- 专利标题： Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
- 专利标题（中）： 使用人G蛋白趋化因子受体HDGNR10（CCR5）进行筛选的方法
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申请号： US09502784申请日： 2000-02-11
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公开(公告)号： US06743594B1公开(公告)日： 2004-06-01
- 发明人: Yi Li , Steven M. Ruben
- 申请人： Yi Li , Steven M. Ruben
- 主分类号： G01N33567
- IPC分类号： G01N33567
摘要：
Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
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