发明授权
- 专利标题： Preparation of sodium-hydrogen exchanger type-1 inhibitors
- 专利标题（中）： 钠 - 氢交换器1型抑制剂的制备
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申请号： US09995133申请日： 2001-11-27
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公开(公告)号： US06753334B2公开(公告)日： 2004-06-22
- 发明人: John F. Lambert , Timothy Norris
- 申请人： John F. Lambert , Timothy Norris
- 主分类号： C07D21538
- IPC分类号： C07D21538
摘要：
This invention relates to methods of preparing sodium-hydrogen exchanger type 1 (NHE-1) inhibitors of formula I′ intermediates of the NHE-1 inhibitors and a new almost colorless form of the NHE-1 inhibitor N-(5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl)-guanidine.