发明授权
US06777576B2 Production method of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid intermediate therefor and production method thereof
失效
2-环己基-2-羟基-2-苯乙酸中间体的制备方法及其制备方法
- 专利标题： Production method of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid intermediate therefor and production method thereof
- 专利标题（中）： 2-环己基-2-羟基-2-苯乙酸中间体的制备方法及其制备方法
-
申请号： US09992167申请日： 2001-11-06
-
公开(公告)号： US06777576B2公开(公告)日： 2004-08-17
- 发明人: Tetsuya Ikemoto , Wei-Guo Gao , Mitsuhiro Takeda , Masami Igi
- 申请人： Tetsuya Ikemoto , Wei-Guo Gao , Mitsuhiro Takeda , Masami Igi
- 优先权： JP2000-339437 20001107
- 主分类号： C07C5940
- IPC分类号： C07C5940
摘要：
The present invention relates to production of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid useful as an intermediate for pharmaceutical products, by an industrial means, economically, safely in a good yield. Novel 2-(2′-cyclohexen-1′-yl)-2-hydroxy-2-phenylacetic acid ester obtained by reacting cyclohexene and benzoylformic acid ester in the presence of a Lewis acid is hydrolyzed and reduced to give 2-cyclohexyl-2-hydroxy-2-phenylacetic acid.
公开/授权文献
信息查询
