发明授权
- 专利标题: Pyrimidine derivatives
- 专利标题(中): 嘧啶衍生物
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申请号: US10130516申请日: 2002-05-16
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公开(公告)号: US06780869B1公开(公告)日: 2004-08-24
- 发明人: Richard Howard Green , Charles David Hartley , Alan Naylor , Jeremy John Payne , Neil Anthony Pegg
- 申请人: Richard Howard Green , Charles David Hartley , Alan Naylor , Jeremy John Payne , Neil Anthony Pegg
- 优先权: GB9927844 19991126
- 主分类号: C07D23942
- IPC分类号: C07D23942
摘要:
The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, C1-6 alkyl, C2-6alkenyl, C3-6alkynyl, C3-10cycloalkylC0-6alkyl or C4-12bridged cycloalkane; and R3 is C1-6alkyl or NH2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of pain, fever, inflammation and a variety of conditions and diseases.
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