发明授权
- 专利标题: Therapeutic compounds
- 专利标题(中): 治疗化合物
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申请号: US09582059申请日: 2000-11-20
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公开(公告)号: US06784186B1公开(公告)日: 2004-08-31
- 发明人: Roy W. Jackson , Kamani R. Subasinghe , Alan L. A. Boura
- 申请人: Roy W. Jackson , Kamani R. Subasinghe , Alan L. A. Boura
- 优先权: AUPP1530 19980129; AUPP3114 19980421; AUPP5046 19980804
- 主分类号: A61K31485
- IPC分类号: A61K31485
摘要:
This invention relates to novel structural analogues and derivatives of compounds with general analgesic or related pharmacological activity. In particular the invention relates to derivatives of opioid compounds, particularly morphine and related compounds, in which an opioid compound is linked via the nitrogen at position 17 to a spacer group, which in turn is linked to a charged group, or a pharmaceutically acceptable salt thereof. In particularly preferred embodiments the opioid compound is morphine, codeine, or buprenorphine.