发明授权
US06787326B1 Interaction between the VHL tumor suppressor and hypoxia inducible factor, and assay methods relating thereto
有权
VHL肿瘤抑制因子和缺氧诱导因子之间的相互作用以及与之相关的测定方法
- 专利标题： Interaction between the VHL tumor suppressor and hypoxia inducible factor, and assay methods relating thereto
- 专利标题（中）： VHL肿瘤抑制因子和缺氧诱导因子之间的相互作用以及与之相关的测定方法
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申请号： US09959873申请日： 2001-11-09
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公开(公告)号： US06787326B1公开(公告)日： 2004-09-07
- 发明人: Peter John Ratcliffe , Patrick Henry Maxwell , Christopher William Pugh
- 申请人： Peter John Ratcliffe , Patrick Henry Maxwell , Christopher William Pugh
- 优先权： GB9911047 19990512
- 主分类号： C12Q154
- IPC分类号： C12Q154
摘要：
The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor &agr; subunits, by targeting HIF &agr; for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF &agr; subunit sequence which may modulate this interaction.
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