发明授权
- 专利标题： Substituted indolinones, their manufacture and their use as medicaments
- 专利标题（中）： 取代的吲哚啉酮，其制造和用作药物
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申请号： US10069557申请日： 2002-07-22
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公开(公告)号： US06794395B1公开(公告)日： 2004-09-21
- 发明人: Gerald Juergen Roth , Armin Heckel , Rainer Walter , Ulrike Tontsch-Grunt , Walter Spevak , Jacobus C. A. Van Meel
- 申请人： Gerald Juergen Roth , Armin Heckel , Rainer Walter , Ulrike Tontsch-Grunt , Walter Spevak , Jacobus C. A. Van Meel
- 优先权： DE19940829 19990827; DE10029285 20000614
- 主分类号： A61K31404
- IPC分类号： A61K31404
摘要：
The present invention relates to substituted indolinones of general formula wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, in particular the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on various receptor-tyrosine kinases, and cycline/CDK complexes as well as on the proliferation of endothelial cells and various tumor cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
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