发明授权
US06800727B2 Peptides with increased + charge and hydrophobicity by substituting one or more amino acids of CA-MA peptide and pharmaceutical compositions containing thereof
失效
通过取代一种或多种CA-MA肽的氨基酸和含有它们的药物组合物，具有增加的+电荷和疏水性的肽
- 专利标题： Peptides with increased + charge and hydrophobicity by substituting one or more amino acids of CA-MA peptide and pharmaceutical compositions containing thereof
- 专利标题（中）： 通过取代一种或多种CA-MA肽的氨基酸和含有它们的药物组合物，具有增加的+电荷和疏水性的肽
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申请号： US10081418申请日： 2002-02-22
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公开(公告)号： US06800727B2公开(公告)日： 2004-10-05
- 发明人: Kyung-Soo Hahm , Dong Gun Lee , YoonKyung Park
- 申请人： Kyung-Soo Hahm , Dong Gun Lee , YoonKyung Park
- 优先权： KR2001-57837 20010919
- 主分类号： A61K3800
- IPC分类号： A61K3800
摘要：
The present invention relates to novel peptides with increased + charge and hydrophobicity by substituting one or more amino acids of CA-MA peptide in which cecropin A (CA) and magainin 2(MA) were conjugated and pharmaceutical compositions containing thereof. More precisely, the present invention relates to synthetic peptides prepared by substituting one or more amino acids of CA-MA peptide represented by the SEQ. ID. NO: 1 with amino acids having + charge and hydrophobicity and anti-bacterial, anti-fungal and anticancer compositions containing thereof. The synthetic peptides of the present invention have no cytotoxicity but have excellent anti-bacterial, anti-fungal and anticancer activity, leading in an effective use thereof as a safe anticancer agent and antibiotics.
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