发明授权
US06800740B1 Variants of native growth hormones having non naturally occurring amino acid sequences or covalent modifications
失效
具有非天然存在的氨基酸序列或共价修饰的天然生长激素的变体
- 专利标题： Variants of native growth hormones having non naturally occurring amino acid sequences or covalent modifications
- 专利标题（中）： 具有非天然存在的氨基酸序列或共价修饰的天然生长激素的变体
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申请号： US08479883申请日： 1995-06-07
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公开(公告)号： US06800740B1公开(公告)日： 2004-10-05
- 发明人: Brian C. Cunningham , James A. Wells
- 申请人： Brian C. Cunningham , James A. Wells
- 主分类号： A61K3827
- IPC分类号： A61K3827
摘要：
Growth hormones contain two receptor binding sites termed site 1 and site 2 with which they form ternary complexes with their receptors. In this scheme, site 1 on the hormone binds to one molecule of receptor and then site 2 binds to another molecule of receptor, thereby producing a 1:2 complex. Disclosed herein are growth hormone variants consisting of modifications to the native sequence in the region of site 1 or site 2, or alternatively a combination of modifications at both site 1 and site 2.
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