发明授权
US06800742B2 Method for producing &bgr;-D-ribofuranose derivatives or optical isomers thereof
失效
制备β-D-呋喃核糖衍生物或其旋光异构体的方法
- 专利标题： Method for producing &bgr;-D-ribofuranose derivatives or optical isomers thereof
- 专利标题（中）： 制备β-D-呋喃核糖衍生物或其旋光异构体的方法
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申请号： US10100909申请日： 2002-03-20
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公开(公告)号： US06800742B2公开(公告)日： 2004-10-05
- 发明人: Yoshihito Koguchi , Takayoshi Torii , Kunisuke Izawa
- 申请人： Yoshihito Koguchi , Takayoshi Torii , Kunisuke Izawa
- 优先权： JP2001-152336 20010522
- 主分类号： C07H1500
- IPC分类号： C07H1500
摘要：
The present invention provides a method for efficiently producing &bgr;-D-ribofuranose derivatives or optical isomers thereof, useful as synthetic intermediates of pharmaceutical nucleic acid-series products. The method comprises a step of producing 1-O-benzyl-&bgr;-D-ribofuranose-2,3,5-triacetate or an optical isomer thereof by allowing &bgr;-D-ribofuranose-1,2,3,5-tetraacetate or an optical isomer thereof to react with a benzyl alcohol in the presence of acid catalysts and a step of hydrolyzing the resulting 1-O-benzyl-&bgr;-D-ribofuranose-2,3,5-triacetate in the presence of a base to produce 1-O-benzyl-&bgr;-D-ribofuranose or an optical isomer thereof.