发明授权
US06803234B2 Gene delivery vectors with cell type specificity for primary human chondrocytes
有权
具有细胞型特异性的原代人软骨细胞的基因递送载体
- 专利标题： Gene delivery vectors with cell type specificity for primary human chondrocytes
- 专利标题（中）： 具有细胞型特异性的原代人软骨细胞的基因递送载体
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申请号： US09928262申请日： 2001-08-10
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公开(公告)号： US06803234B2公开(公告)日： 2004-10-12
- 发明人: Menzo Havenga , Ronald Vogels , Abraham Bout
- 申请人： Menzo Havenga , Ronald Vogels , Abraham Bout
- 优先权： EP00202835 20000810
- 主分类号： C12N1586
- IPC分类号： C12N1586
摘要：
The present invention relates to a gene delivery vehicle comprising a recombinant adenovirus having a tropism for a primary human chondrocyte. By efficiently transducing a nucleic acid of interest into a primary chondrocytes, the gene delivery vehicle is able to at least in part improve the counteraction of cartilage disease. In one embodiment the recombinant adenovirus comprises a deletion in the gene encoding for fiber protein, which is replaced by a nucleic acid sequence encoding at least part of a fiber protein of a B-type adenovirus.
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