发明授权
- 专利标题： Methods for the identification of inhibitors of threonine synthase as antibiotics
- 专利标题（中）： 鉴定苏氨酸合酶抑制剂作为抗生素的方法
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申请号： US10011106申请日： 2001-12-07
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公开(公告)号： US06806060B2公开(公告)日： 2004-10-19
- 发明人: Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo
- 申请人： Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo
- 主分类号： C12Q118
- IPC分类号： C12Q118
摘要：
The present inventors have discovered that Threonine synthase is essential for fungal pathogenicity. Specifically, the inhibition of Threonine synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Threonine synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
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