A molecular recognition sensor system for detecting the presence and concentration of an analyte including a resistive sensor having a semiconductive polymer film which swells when exposed to an analyte and interferents and a molecular imprinted resistive sensor having a semiconductive polymer film imprinted with the analyte which thereby swells when exposed to interferents, a circuit connected to the resistive sensor and the molecular imprinted resistive sensor for detecting a change in the resistance of the resistive sensor when exposed to the analyte and the interferents, the change in the resistance of the molecular imprinted resistive sensor when exposed to the analyte and interferents, and for subtracting the change in resistance of the molecular imprinted resistive sensor from the change in resistance of the resistive sensor to reduce the effect of any interferents on the change in resistance of the resistive sensor thereby determining the presence and concentration of the analyte.