An alignment system for co-aligning multiple laser beams to a single spatial reference point in real time. The alignment system includes a beam sampler for sampling the multiple pulsed laser beams. The sampled laser beams are directed onto a quadrant photo detector or quad cell. The output signals from the quad cell are directed to a detector signal integration circuit which develops error signals for driving tip-tilt mirrors in the beam path of the multiple lasers. The system includes a gate, reset and pulse ID generator for generating pulse trigger signals for each of the multiple lasers and signals for correlating the detector signals with the laser that produced the signal. Accordingly, a system is provided for a time multiplexed, multiple laser system which automatically co-aligns the output beams from each of the lasers to a single spatial reference point in real time.