A method, computer program product, and distributed data processing system for lazy deregistration of memory regions. Specifically, the present invention is directed to memory regions that are written to and from by an Integrated Protocol Suite Offload Engine (IPSOE) in accordance with a preferred embodiment of the present invention. A mechanism is provided for lazy deregistration of memory regions once the region is no longer required for a specific data transfer being carried out by the IPSOE. Rather than deregistering a memory region after a data transfer has been carried out, the memory region remains registered for some selected period of time. After that selected period of time passes, the region is then deregistered. If a second data transfer using this memory region occurs while the memory region is still registered, the registration overhead is avoided for this second data transfer. This mechanism reduces the amount of CPU resources required for transferring data by allowing reuse of previously registered memory regions.