A method of generating synthesis scripts to synthesize integrated circuit (IC) designs described in a generic netlist into a gate-level description includes the steps of identifying hardware elements in a generic netlist, determining key pins for each of the identified hardware elements, extracting design structure and hierarchy from the generic netlist, generating script to cause a logic synthesis tool to apply bottom-up synthesis to modules and sub-modules of the IC design, generating script to cause a logic synthesis tool to apply top-down characterization to modules and sub-modules of the IC design, and generating script to cause a logic synthesis tool to repeat these bottom-up and top-down applications until constraints are satisfied.