发明授权
- 专利标题: Process for the production of a racemic thioctic acid
- 专利标题(中): 制备外消旋硫辛酸的方法
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申请号: US10398891申请日: 2001-10-08
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公开(公告)号: US06844450B2公开(公告)日: 2005-01-18
- 发明人: Annibale Salvi , Stefano Maiorana , Francesco Corcella
- 申请人: Annibale Salvi , Stefano Maiorana , Francesco Corcella
- 申请人地址: IT Milan
- 专利权人: Laboratorio Chimico Internazionale S.p.A.
- 当前专利权人: Laboratorio Chimico Internazionale S.p.A.
- 当前专利权人地址: IT Milan
- 代理机构: Nixon Peabody LLP
- 优先权: ITMI2000A2186 20001010
- 国际申请: PCTEP01/11577 WO 20011008
- 国际公布: WO0230917 WO 20020418
- 主分类号: C07D339/04
- IPC分类号: C07D339/04 ; C07D341/00
摘要:
Process for the synthesis of racemic thioctic acid comprising the following stages: a) reaction of the alkyl ester of 6,8-di-halo-octanoic acid in an organic solvent with an aqueous solution of alkali disulfide in presence of a compound for phase transfer catalysis selected from the group consisting of quaternary ammonium or phosphonium salts having the following general formula: where: A is nitrogen of phosphorus, X is selected from the group consisting of Cl, Br, I, HSO4, and H2PO4 and the substitutents R1, R2, R3 and R4 are selection from the group consisting of linear or branched alkyl radicals having one to twenty carbon atoms (C1-C20), said substituents being identical or different one from the other, or only one of said substituents is selected from the group consisting of arylalkyl radicals having the following formula —(CH2)nC6H5 in which n=1-16; b) followed by the hydrolysis of the ester of racemic thiotic acid.
公开/授权文献
- US20040030157A1 Process for the production of a racemic thioctic acid 公开/授权日:2004-02-12