发明授权
- 专利标题： Substituted indoles and their use as integrin antagonists
- 专利标题（中）： 取代的吲哚及其作为整联蛋白拮抗剂的用途
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申请号： US10058215申请日： 2002-01-29
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公开(公告)号： US06855722B2公开(公告)日： 2005-02-15
- 发明人: Tianbo Lu , Louis V. LaFrance , Thomas P. Markotan , Juan J. Marugan Sanchez , Victor J. Marder , David C. U'Prichard , Beth M. Anaclerio , Zihong Guo , Wenzi Pan , Kristi A. Leonard , Bruce E. Tomczuk
- 申请人： Tianbo Lu , Louis V. LaFrance , Thomas P. Markotan , Juan J. Marugan Sanchez , Victor J. Marder , David C. U'Prichard , Beth M. Anaclerio , Zihong Guo , Wenzi Pan , Kristi A. Leonard , Bruce E. Tomczuk
- 申请人地址： US PA Exton
- 专利权人： Dimensional Pharmaceuticals, Inc.
- 当前专利权人： Dimensional Pharmaceuticals, Inc.
- 当前专利权人地址： US PA Exton
- 代理机构： Woodcock Washburn LLP
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; A61K31/4375 ; A61K31/4439 ; A61K31/4709 ; A61K31/5383 ; A61P3/06 ; A61P3/10 ; A61P7/06 ; A61P9/00 ; A61P9/10 ; A61P19/10 ; A61P25/00 ; A61P25/04 ; A61P25/08 ; A61P25/18 ; A61P25/22 ; A61P27/02 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07D209/08 ; C07D213/74 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D471/04 ; C07D498/04
摘要：
The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.
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