发明授权
US06864244B2 Anhydrous crystalline 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine hemisulfate as useful as an antiviral agent
失效
含水结晶4-氨基-1 - （（2r，3r，4s，5r）-5-叠氮基-3,4-二羟基-5-羟甲基 - 四氢 - 呋喃-2-基）-1H-嘧啶-2-酮
![Anhydrous crystalline 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine hemisulfate as useful as an antiviral agent](/docs/US/2005-03-08/US06864244B2/abs.jpg.600x600.jpg)
- 专利标题： Anhydrous crystalline 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine hemisulfate as useful as an antiviral agent
- 专利标题（中）： 含水结晶4-氨基-1 - （（2r，3r，4s，5r）-5-叠氮基-3,4-二羟基-5-羟甲基 - 四氢 - 呋喃-2-基）-1H-嘧啶-2-酮
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申请号： US10731582申请日： 2003-12-09
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公开(公告)号： US06864244B2公开(公告)日： 2005-03-08
- 发明人: Terrence Joseph Connolly , Joseph Armstrong Martin , Anthony Prince , Keshab Sarma
- 申请人： Terrence Joseph Connolly , Joseph Armstrong Martin , Anthony Prince , Keshab Sarma
- 申请人地址： US CA Palo Alto
- 专利权人： Roche Palo Alto LLC
- 当前专利权人： Roche Palo Alto LLC
- 当前专利权人地址： US CA Palo Alto
- 代理商 Brian L. Buckwalter
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/7052 ; A61K31/7068 ; A61K31/7072 ; A61P31/12 ; C07H19/06 ; C07H19/067
![Anhydrous crystalline 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine hemisulfate as useful as an antiviral agent](/abs-image/US/2005/03/08/US06864244B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to the hemisulfate salt of 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine (Ia) with improved stability and physical properties which facilitate manufacturing, handling and formulating I and polymorphic crystalline forms thereof.