An air-blow valve configured for clean-in-place capability is provided. The valve comprises a valve body defining a valve seat and internal fluid passageways. The valve further comprises valve components disposed within the valve body, including a plug, a piston, and a spring. The valve is separately operatively connected to a pressurized-air source and to a sanitizing-fluid source. In operation, the spring biases the piston, causing the plug to engage the seat, to prevent undesired fluid flow between the passageways and the connecting conduits. Alternatively, the spring biases the piston, causing the plug to disengage the seat, allowing fluid flow between the passageways and connecting conduits. Pressurized air is used to space the plug from the seat to achieve flow whenever desired, or alternatively to engage the seat to prevent fluid flow when desired. Periodic selective movement of the piston to space the plug from the seat, enables the cleaning solution to pass through the body and clean the internal passageways, the seat, and the plug, thereby rendering unnecessary disassembly of the valve and/or removal of the valve from the connecting conduits during valve cleaning.