发明授权
- 专利标题: Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
- 专利标题(中): 制备含有微晶纤维素的直接可压缩固体剂型的方法
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申请号: US10015538申请日: 2001-12-13
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公开(公告)号: US06866867B2公开(公告)日: 2005-03-15
- 发明人: John N. Staniforth , Bob E. Sherwood , Edward A. Hunter , Clifford M. Davidson
- 申请人: John N. Staniforth , Bob E. Sherwood , Edward A. Hunter , Clifford M. Davidson
- 申请人地址: DE Rosenberg
- 专利权人: J. Rettenmaier & Soehne GmbH + Co. KG
- 当前专利权人: J. Rettenmaier & Soehne GmbH + Co. KG
- 当前专利权人地址: DE Rosenberg
- 代理机构: Davidson, Davidson & Kappel, LLC
- 主分类号: A61K9/20
- IPC分类号: A61K9/20 ; A61K9/22 ; A61K9/14 ; A61K9/28
摘要:
The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.
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