发明授权
- 专利标题： Microprecipitation method for preparing submicron suspensions
- 专利标题（中）： 制备亚微米悬浮液的微沉淀法
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申请号： US09874637申请日： 2001-06-05
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公开(公告)号： US06869617B2公开(公告)日： 2005-03-22
- 发明人: James E. Kipp , Joseph Chung Tak Wong , Mark J. Doty , Christine L. Rebbeck
- 申请人： James E. Kipp , Joseph Chung Tak Wong , Mark J. Doty , Christine L. Rebbeck
- 申请人地址： US IL Deerfield
- 专利权人： Baxter International Inc.
- 当前专利权人： Baxter International Inc.
- 当前专利权人地址： US IL Deerfield
- 代理商 Michael C. Mayo; Joseph A. Fuchs
- 主分类号： A61K
- IPC分类号： A61K20060101 ; A61K9/10 ; A61K9/14 ; A61K9/16 ; A61K31/495 ; A61K31/496 ; B01J13/00
摘要：
The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.