发明授权
US06869924B1 Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body, and the cloning of full length cDNA thereof
失效
人源性单核细胞吸引用于治疗人体感染和赘生物的方法的纯化蛋白质产物，以及克隆其全长cDNA
- 专利标题： Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body, and the cloning of full length cDNA thereof
- 专利标题（中）： 人源性单核细胞吸引用于治疗人体感染和赘生物的方法的纯化蛋白质产物，以及克隆其全长cDNA
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申请号： US07330446申请日： 1989-03-30
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公开(公告)号： US06869924B1公开(公告)日： 2005-03-22
- 发明人: Teizo Yoshimura , Elizabeth A. Robinson , Ettore Appella , Edward J. Leonard
- 申请人： Teizo Yoshimura , Elizabeth A. Robinson , Ettore Appella , Edward J. Leonard
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Merchant & Gould P.C.
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/52 ; C07K14/00
摘要：
Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. The cloning of full length cDNA for the peptide products is also provided, as well as recombinant methods for the production of monocyte chemoattractant products. Methods of treating infection and neoplasms in a human body with such peptides and monocyte chemoattractant products are additionally provided, as well as pharmaceutical compositions for the same.
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