发明授权
US06869956B2 Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)
失效
使用IkappaB激酶抑制剂（IKK）治疗炎症和免疫疾病的方法
- 专利标题： Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)
- 专利标题（中）： 使用IkappaB激酶抑制剂（IKK）治疗炎症和免疫疾病的方法
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申请号： US10062847申请日： 2002-02-01
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公开(公告)号： US06869956B2公开(公告)日： 2005-03-22
- 发明人: James R. Burke , Robert M. Townsend , Yuping Qiu , Fred Christopher Zusi , Steven G. Nadler
- 申请人： James R. Burke , Robert M. Townsend , Yuping Qiu , Fred Christopher Zusi , Steven G. Nadler
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 John A. Lamerdin; Audrey F. Sher
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; A61K31/519 ; A61P1/00 ; A61P11/06 ; A61P19/02 ; A61P37/06 ; C07D471/04 ; C07D487/04 ; C07D513/04
摘要：
The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of IκB kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and immune-related diseases or disorders, as demonstrated in vivo. Further embodiments of the present invention relate to a specific IKK inhibitors, 4(2′-aminoethyl)amino-1,8-dimethylimidazo(1,2-a) quinoxaline and compounds of formula (I), salts thereof, and pharmaceutical compositions.
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