发明授权
- 专利标题： UCS1025 derivatives
- 专利标题（中）： UCS1025衍生品
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申请号： US10110964申请日： 2000-10-19
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公开(公告)号： US06869971B1公开(公告)日： 2005-03-22
- 发明人: Tsutomu Akama , Akira Asai , Tsutomu Agatsuma , Shinji Nara , Yoshinori Yamashita , Tamio Mizukami , Shun-ichi Ikeda , Yutaka Saitoh , Yutaka Kanda
- 申请人： Tsutomu Akama , Akira Asai , Tsutomu Agatsuma , Shinji Nara , Yoshinori Yamashita , Tamio Mizukami , Shun-ichi Ikeda , Yutaka Saitoh , Yutaka Kanda
- 申请人地址： JP Tokyo
- 专利权人： Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人： Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Fitzpatrick, Cella, Harper & Scinto
- 优先权： JP11298972 19991021
- 国际申请： PCTJP00/07287 WO 20001019
- 国际公布： WO0129043 WO 20010426
- 主分类号： A61P31/04
- IPC分类号： A61P31/04 ; A61P35/00 ; C07D487/04 ; C07D487/14 ; C07D487/16 ; C07D491/14 ; C07D491/147 ; C07D491/16 ; C07D498/08 ; A61K31/403 ; A61K31/4453 ; C07D209/52 ; C07D401/06
摘要：
UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I): wherein R1 represents hydrogen, lower alkyl, etc.; R2 represents hydrogen, or is combined with R3 to represent a bond, etc., or is combined with R4 to represent —O(C═O)—, etc.; R3 represents hydrogen, etc., or is combined with R2 to represent a bond, etc.; R4 represents hydrogen, etc., or is combined with R2 to represent —(C═O)O—, etc.; R5 represents hydrogen or is combined with R6 to represent a bond; R6 represents hydrogen, etc., or is combined with R5 to represent a bond; R7 represents hydrogen or is combined with R8 to represent ═O; R8 represents hydroxy or is combined with R7 to represent ═O; ---- represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.
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