发明授权
US06872730B2 Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
有权
取代的苯并呋喃和苯并噻吩，其制备方法和用作整联蛋白拮抗剂的方法
- 专利标题： Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
- 专利标题（中）： 取代的苯并呋喃和苯并噻吩，其制备方法和用作整联蛋白拮抗剂的方法
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申请号： US10132706申请日： 2002-04-26
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公开(公告)号： US06872730B2公开(公告)日： 2005-03-29
- 发明人: Beth M. Anaclerio , Juan J. Marugan Sanchez , Victor J. Marder , David C. U'Prichard , Bruce E. Tomczuk
- 申请人： Beth M. Anaclerio , Juan J. Marugan Sanchez , Victor J. Marder , David C. U'Prichard , Bruce E. Tomczuk
- 申请人地址： US PA Exton
- 专利权人： 3-Dimensional Pharmaceuticals, Inc.
- 当前专利权人： 3-Dimensional Pharmaceuticals, Inc.
- 当前专利权人地址： US PA Exton
- 代理机构： Woodcock Washburn LLP
- 主分类号： A61K31/4375
- IPC分类号： A61K31/4375 ; A61K31/443 ; A61K31/4436 ; A61P3/08 ; A61P7/06 ; A61P9/10 ; A61P19/02 ; A61P19/10 ; A61P25/00 ; A61P25/04 ; A61P25/18 ; A61P25/22 ; A61P25/28 ; A61P25/36 ; A61P29/00 ; A61P35/00 ; C07D405/12 ; C07D409/12 ; C07D471/04 ; A61K31/381 ; A61K31/5383
摘要：
The present invention relates to novel substituted benzofurans and benzothiophenes compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula I: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, n, i, j and k are defined herein.
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