发明授权
- 专利标题: sPLA2 inhibitors
- 专利标题(中): sPLA2抑制剂
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申请号: US10450633申请日: 2001-12-06
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公开(公告)号: US06872743B2公开(公告)日: 2005-03-29
- 发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer
- 申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer
- 申请人地址: US IN Indianapolis
- 专利权人: Eli Lilly and Company
- 当前专利权人: Eli Lilly and Company
- 当前专利权人地址: US IN Indianapolis
- 代理商 Francis O. Ginah
- 国际申请: PCTUS01/43185 WO 20011206
- 国际公布: WO0250034 WO 20020627
- 主分类号: A61K31/403
- IPC分类号: A61K31/403 ; A61P1/00 ; A61P1/18 ; A61P7/00 ; A61P11/00 ; A61P11/06 ; A61P17/02 ; A61P17/06 ; A61P19/02 ; A61P19/06 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07D209/80 ; C07D209/94 ; C07D209/56
摘要:
A novel class of tetracyclic compounds represented by the formula I wherein R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, and n are as defined is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
公开/授权文献
- US20040063941A1 Novel spla2 inhibitors 公开/授权日:2004-04-01